Hello,
To answer your question, the setting for Memory Mapped I/O above 4GB should be enable when using a GPGPU or Xeon Phi Coprocessor,not a regular card as you are using. Also the AMD 6450 is not a validated hardware component for the board so we recommend using one of the tested cards previously mentioned to narrow the issue and based on that we can jump into conclusions. We also recommend contacting AMD directly to address this issue.
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Re: Unable to passthrough GPU (AMD 6450), Intel 2600IP4 motherboard, esxi 6.0u2
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